Antikoerper und Interferone

Es gibt doch bestimmt den ein oder anderen unter uns, der sich für Antikörper. Spannende Neuigkeiten dazu findet ihr auf antikoerper.de.

Hallo an alle,

die Firma Antikörper-Online hat jetzt auch noch eine französische Internetseite. Schaut doch einfach mal rein.

http://www.anticorps-enligne.fr/

Hi Guys,

ich hoffe der Blog gefällt euch und ihr konntet einige interessante Infos mitnehmen.

Damit das auch weiterhin so bleibt, werde ich in nächster Zeit wieder aktiver bloggen.

Beste Grüße
Franz

Hier gibts im Web ein neues Portal für Krankenhausstellen. Krankenschwestern, Pfleger und Ärzte finden hier jede Menge freie Stellen im Klinikbereich. Einfach mal reinschauen wird sich sicher lohnen.

So far the industry stood for the established purification procedures are available, although reliable but are not very flexible and development-intensive and thus expensive. Regarding scale, purity, or freedom from contamination should the procedure for the purification of pharmaceutical proteins are constantly adapted to the growing demands, says Kiefer. Other hand, are desirable in so-called downstream processing, process steps are carried out continuously to behave robust against variations in process parameters and use inexpensive materials that governmental regulation of the biopharmaceutical product manufacturing meet (Good Manufacturing Practice).

Within the BMBF-project will be explored in an interdisciplinary collaboration between biologists, biochemists, chemists and process engineers, as the technical protein crystallization can be considered as a novel separation process for biopharmaceuticals, particularly antibodies, are used. The process was scaled up so far that a transfer was to ensure production standards on the industry, says Kiefer.

Next would be sought with the physico-chemical methods of optimum conditions under which the protein can crystallize without loss of activity, describes Professor Pine's approach. It will initially rely on screening procedures, which are common in structural biology. Subsequently, detailed phase diagrams were created to allow a subsequent process control. The demands of the industry in this process were clearly defined from the outset by the pharmaceutical companies, achieved so that economic viability is ensured once the milestones are.

Alzheimer's disease may still not be cured. The positive impact of currently approved drugs to existing symptoms is relatively low; they cannot slow down the progression of the disease. In 2006 was published by the American Association for Geriatric Psychiatry, a consensus paper on Alzheimer's treatment.

Acetylcholinesterase inhibitors

The drugs to ensure that AC is broken down more slowly in the brain and therefore present in higher concentrations, thereby reducing the AC-levels by the death of neurons that produce this neurotransmitter to reverse. Representatives of this group are drug galantamine, donepezil and rivastigmine. The effectiveness of the therapy is discussed. The ideal revealed study is that both the patch application, as well as the oral administration of rivastigmine, the cognitive abilities of patients is significantly improved compared with placebo. But there are also studies that show a small effect of acetylcholinesterase inhibitors.

Ibuprofen and other nonsteroidal anti-inflammatory drugs

in retrospective studies it was found in 1995 that rheumatic patients have a significantly reduced risk of developing Alzheimer's disease, or later the disease broke out among them than with Nichtrheumatikern. It was concluded that this effect is referred to the nonsteroidal anti-inflammatory drugs (NSAIDs) (in English-language publications nonsteroidal anti-inflammatory drugs (NSAIDs) result), taking these patients.

In some transgenic animal models, a reduction of amyloid (Aβ) plaques could be detected in the administration of ibuprofen.

In humans so far no data are available from randomized double-blind studies that demonstrate a secure mode of action of ibuprofen and other nonsteroidal anti-inflammatory drugs. Because of the significant side effects that are expected for a permanent prophylactic administration of ibuprofen, it is uncontrollable from one administration discouraged. The measures necessary for the possible prevention of Alzheimer's disease antibodies, doses of nonsteroidal anti-inflammatory drugs are much higher than the normal pain treatment. The nonsteroidal anti-inflammatory drugs induce are suspected cardiovascular problems when they are taken on time and in high doses.

With ibuprofen and derivatives of ibuprofen are currently running for a number of clinical trials in Alzheimer's patients

NMDA receptor antagonist

The influence of the neurotransmitter glutamate, the most common excitatory neurotransmitter in the central nervous system is involved in learning and memory functions, was in Europe in 2002 and in the USA in 2003 approved. The industry's only representative of this drug class is memantine. This is an NMDA receptor (N-methyl-D-aspartate) receptor antagonist and is intended normalize impaired in Alzheimer's dementia glutamatergic signal transmission. Study results show that memantine results in moderate to severe disease after six months to a slight overall improvement in cognitive impairment and impaired activities of daily living.

Herzlich Willkommen auf meinem Weblog!

Hier möchte ich von nun an in regelmäßigen Abständen Artikel und Beiträge aus dem Bereich der Antikörperforschung veröffentlichen.

Allen interessierten Lesern wünsche ich viel Spass!!